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Formulation Highlight: Lamellar Structure that Enhances Skin Affinity

We highlight the formula selections that have lamellar structure with high penetration perfomance using "NIKKOL WAX-230", nonionic self-emulsifying wax consisting of polyoxyethylene (20) arachidyl ether and stearyl alcohol.

By mixing 5-10%, emulsions with lamellar liquid crystal structure similar to intercellular lipids in skin can be prepared without considering HLB. The water retained in the liquid crystal structure enhances water retention capacity of the skin.

In addition, by incorporating the actives into the lamellar structure, crystallization can be prevented, resulting in a stable emulsion. NIKKOL WAX-230 is suitable for various topical formulations, such as petrolatum creams, urea milky lotions, and indomethacin creams.

Formula Proposal

PH006 Emulsion lotion (Lot. 34-WXM-21)

  • Base: NIKKOL WAX-230 2%

  • Spreads well, and gives a moist feeling

  • Main component is polar oil, it is effective in dissolving drugs

PH004  O/W Cream (Lot. 49-WUM-9)

  • Base: NIKKOL WAX-230 4%

  • Contains 20% urea

  • Spreads richly on skin and gives moist feeling

  • Enhance the water retention capacity of the skin

PH002 O/W Cream (Lot No.27-WAX-61)

  • Base: NIKKOL WAX-230 8% + Behenyl Alcohol 2%

  • Contains 1% indomethacin

  • Spreads richly on skin

  • Achieves a balance between a moisturizing feel and a nontacky finish

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