"Mini-RNA" - Strengthen Skin Barrier from Cellular Level

Inspired by Infant Skin: Unlocking Next-Gen Barrier Renewal

  • 5'-Cytidine Monophosphate

  • Nucleotide

  • Long-chain ceramides

  • Skin barrier repair

Enzymatically-cleaved RNA for barrier lipoquality enhancement.

  • Usage
    Skin care, Point makeup (e.g. eye makeup), Base makeup (e.g. foundation), Sun care (e.g. sunscreen), Hair care
  1. Features
  2. Product Overview / Downloads

Features

Concept: Resilience rooted in nature of breast milk

Newborn skin is exceptionally delicate - up to five times thinner than adult skin - leaving it uniquely vulnerable to harsh environmental triggers like UV rays and dehydration.

Nature counters this sensitivity through breast milk, where 5'-CMP serves as the dominant nucleotide. In infants, this vital molecule drives lipid metabolism to fortify the protective barrier of gut epithelial cells. By capturing this natural biological wisdom, 5’-CMP transforms a fundamental mechanism of early survival into an advanced ingredient for modern skincare.

The product name of 5’-CMP is CMP,2Na-PC

Bar chart comparing nucleotide levels in breast milk showing 5'-CMP as the most abundant nucleotide

The nucleotide science: Strengthening the barrier architecture

5’-CMP is 4,000 times smaller than salmon PDRN (1500kDa), which delivers unmatched skin penetration and bioavailability.

Functioning as a vital phosphate donor within essential lipid metabolic pathways, 5’-CMP leverages lipidomic research to optimize skin barrier mechanics. It selectively upregulates the synthesis of key epidermal components - phosphatidylcholine and long-chain ceramides.

In vitro lipidomic data using a 3D epidermal model confirms that 5’-CMP helps promote the synthesis of longer chain fatty acids. This marks a major advancement in skin repair: while compromised or atopic skin frequently suffers from shortened ceramide chains, 5'-CMP encourages longer-chain synthesis—resulting in a denser, highly resilient cutaneous structure.

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In vitro test data chart showing 5'-CMP significantly increasing the synthesis of phosphatidylcholine and longer-chain fatty acids

Lipidomic data graph demonstrating 5'-CMP promoting the synthesis of long-chain ceramides (C22:1 and C24:1) for skin barrier repair

Clinical efficacy with 5’-CMP

For clinical data on dry lines improvement and skin hydration, please check the technical document below.

Product Overview / Downloads

Specifications

Product NameCMP,2NA-PC
Chemical NameCytidine 5’-monophosphate, disodium salt
INCI NameDISODIUM CYTIDINE PHOSPHATE
Standards

JSQI=The Japanese Standards of Quasi-Drug Ingredients
JPE=Japanese Pharmaceutical Excipients
JSFA=Japan's Specifications and Standards for Food Additives
IB=Confidential Specification of Quasi-drug ingredients made available by owner for public reference
Confidential Spec=Confidential Specification of Quasi-drug ingredients

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China’s cosmetic ingredient submission code
Yes
RSPO
Palm derivative-free
Natural origin index
Process water included: 1
Process water not included: 1
Package size and type
1kg/paper bag、/
CAS RN®
6757-06-8
Tariff code (H.S. Code)
2934.99
  • HLB is measured by O/W emulsification test.
  • IOB is calculated using representative values of fatty acid composition. The influence of extracts is not taken into consideration.
  • Although every effort has been made to ensure the accuracy of this document, no warranties are expressed or implied as to its contents. For product specifications and quality, please contact our sales department.
  • Some ingredients are not permitted to be sold in certain countries. Please contact our sales department for details.

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