PICK UP: Transparent Topical Formula Selections

What key factors do you consider when developing a new gel-based topical formulation?

In recent years, consumer expectations for OTC topical formulations have expanded to include not only efficacy and safety but also favorable texture, appearance, and sensory characteristics.

Here, we spotlight three distinctive transparent topical formulations with good skin affinity, each suitable for a wide range of applications.

Let’s explore their differences and discover the unique strengths of each — to help inspire your next development project.

Comparison of Three Transparent Formulas

	1. Petrolatum Ointment	2. Clear Ointment with NIKKOL DOP-8NV	3. Clear Gel with Carboxyvinyl Polymer
Elasticity	Rich texture	Rich texture	Light texture
Finish	Moisturizing and occlusive	Moisturizing without stickiness	Refreshing
Alcohol	Free	Free	Required for solubilizing actives
Oil-soluble actives	Easily incorporated	Easily incorporated	Difficult to incorporate
Water-soluble actives	Difficult to incorporate	Easily incorporated	Depends on actives

Formula Proposal

1. Petrolatum Ointment

Features

- Spreads slowly with occlusive feel

- Prevents water loss and retains skin hydration

2. Clear Ointment with NIKKOL DOP-8NV

Features

- Spreads richly and absorb in the skin

- Lighter touch than petrolatum ointment

- Alcohol free

*Lot No. 36-PRG-1

Key Ingredients

- NIKKOL DOP-8NV: 　It has excellent solubility in water and organic solvents and emulsifying, solubilizing and dispersing ability over a wide pH range.

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